Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Dixie Heights | at nippert stadium, university of cincinnati | W | 35–28 | 1-0 | ||
| Fri, Aug 27, 2010 | Aiken, OH | home | W | 44–6 | 2-0 | ||
| Fri, Sep 3, 2010 | Madison Central | home | W | 45–3 | 3-0 | ||
| Fri, Sep 10, 2010 | Ryle | away | L | 7–27 | 3-1 | ||
| Fri, Sep 17, 2010 | Campbell County | away | W | 26–23 | 4-1 | ||
| Fri, Sep 24, 2010 | Covington Catholic | home | W | 38–31 | 5-1 | ||
| Fri, Oct 1, 2010 | Newport | away | W | 54–13 | 6-1 | ||
| Fri, Oct 8, 2010 | Holy Cross (Covington) | away | W | 28–14 | 7-1 | ||
| Fri, Oct 22, 2010 | Lloyd Memorial | home | W | 56–7 | 8-1 | ||
| Sat, Oct 30, 2010 | Beechwood | home | L | 39–40 | 8-2 | (double overtime) | |
| Fri, Nov 5, 2010 | Owen County | at newport | W | 70–20 | 9-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Christian Academy-Louisville | home | W | 51–21 | 10-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Holy Cross (Covington) | home | W | 56–21 | 11-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Corbin | away | W | 42–8 | 12-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Dec 3, 2010 | Owensboro Catholic | at houchens-l.t. smith stadium, wku | W | 42–0 | 13-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl |