Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Dixie Heights | home | L | 21–35 | 0-1 | ||
| Fri, Sep 3, 2010 | Highlands | away | L | 24–50 | 0-2 | ||
| Sat, Sep 11, 2010 | Holy Cross (Covington) | at bellevue | W | 28–21 | 1-2 | ||
| Fri, Sep 17, 2010 | Covington Catholic | home | L | 21–24 | 1-3 | ||
| Fri, Sep 24, 2010 | Dayton | away | W | 49–0 | 2-3 | ||
| Fri, Oct 1, 2010 | Walton-Verona | home | W | 55–20 | 3-3 | ||
| Fri, Oct 8, 2010 | Ludlow | away | W | 58–7 | 4-3 | ||
| Fri, Oct 15, 2010 | Bishop Brossart | home | W | 49–0 | 5-3 | ||
| Fri, Oct 22, 2010 | Bellevue | home | W | 52–7 | 6-3 | ||
| Sat, Oct 30, 2010 | Newport Central Catholic | away | W | 40–39 | 7-3 | (double overtime) | |
| Fri, Nov 5, 2010 | Gallatin County | home | W | 55–0 | 8-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Bellevue | home | W | 63–7 | 9-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Frankfort | away | W | 56–13 | 10-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Mayfield | home | L | 14–38 | 10-4 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl |