Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Newport Central Catholic | at nippert stadium, university of cincinnati | L | 28–35 | 0-1 | ||
| Fri, Aug 27, 2010 | Beechwood | away | W | 35–21 | 1-1 | ||
| Fri, Sep 3, 2010 | Simon Kenton | home | L | 28–31 | 1-2 | ||
| Fri, Sep 10, 2010 | Conner | home | W | 41–26 | 2-2 | ||
| Fri, Sep 17, 2010 | Ryle | away | L | 7–20 | 2-3 | ||
| Fri, Sep 24, 2010 | Scott | home | W | 56–12 | 3-3 | ||
| Fri, Oct 1, 2010 | Highlands | home | L | 14–42 | 3-4 | ||
| Fri, Oct 8, 2010 | Holmes | home | W | 47–20 | 4-4 | ||
| Sat, Oct 23, 2010 | Covington Catholic | away | L | 36–40 | 4-5 | ||
| Fri, Oct 29, 2010 | Boone County | away | W | 41–16 | 5-5 | ||
| Fri, Nov 5, 2010 | Montgomery County | away | W | 42–20 | 6-5 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Highlands | away | L | 28–42 | 6-6 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl |