Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | DuPont Manual | home | W | 45–14 | 1-0 | ||
| Fri, Aug 27, 2010 | Ryle | home | W | 29–14 | 2-0 | ||
| Fri, Sep 3, 2010 | Beechwood | home | W | 50–24 | 3-0 | ||
| Fri, Sep 10, 2010 | Withrow, OH | home | W | 34–27 | 4-0 | ||
| Fri, Sep 17, 2010 | Boone County | away | W | 55–0 | 5-0 | ||
| Sat, Sep 25, 2010 | Eastern | away | W | 46–0 | 6-0 | ||
| Fri, Oct 1, 2010 | Dixie Heights | away | W | 42–14 | 7-0 | ||
| Fri, Oct 15, 2010 | Covington Catholic | home | W | 27–20 | 8-0 | ||
| Fri, Oct 22, 2010 | Scott | away | W | 33–7 | 9-0 | ||
| Thu, Oct 28, 2010 | Ryle | away | L | 26–28 | 9-1 | ||
| Fri, Nov 5, 2010 | Woodford County | home | W | 70–8 | 10-1 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Dixie Heights | home | W | 42–28 | 11-1 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Johnson Central | away | W | 21–14 | 12-1 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Harlan County | away | W | 34–6 | 13-1 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Sat, Dec 4, 2010 | Christian County | at houchens-l.t. smith stadium, wku | W | 50–0 | 14-1 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl |