Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Covington Catholic | at nippert stadium, university of cincinnati | W | 61–7 | 1-0 | ||
| Fri, Aug 27, 2010 | Highlands | away | L | 14–29 | 1-1 | ||
| Fri, Sep 10, 2010 | Newport Central Catholic | home | W | 27–7 | 2-1 | ||
| Fri, Sep 17, 2010 | Dixie Heights | home | W | 20–7 | 3-1 | ||
| Fri, Sep 24, 2010 | Cooper | away | W | 28–21 | 4-1 | ||
| Fri, Oct 1, 2010 | Campbell County | home | W | 35–30 | 5-1 | ||
| Fri, Oct 8, 2010 | Simon Kenton | home | W | 38–35 | 6-1 | overtime | |
| Fri, Oct 15, 2010 | Conner | away | W | 49–6 | 7-1 | ||
| Fri, Oct 22, 2010 | Boone County | away | W | 42–21 | 8-1 | ||
| Thu, Oct 28, 2010 | Highlands | home | W | 28–26 | 9-1 | ||
| Fri, Nov 5, 2010 | Madison Central | home | W | 54–13 | 10-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Campbell County | home | W | 38–14 | 11-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Simon Kenton | home | W | 35–14 | 12-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Trinity (Louisville) | home | L | 9–28 | 12-2 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |