Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Lawrence North, IN | away | W | 56–23 | 1-0 | ||
| Fri, Sep 3, 2010 | DuPont Manual | away | W | 42–7 | 2-0 | ||
| Fri, Sep 10, 2010 | Cincinnati Elder, OH | home | W | 22–20 | 3-0 | ||
| Fri, Sep 17, 2010 | Cincinnati St. Xavier, OH | home | L | 10–17 | 3-1 | ||
| Fri, Sep 24, 2010 | Bowling Green | away | W | 14–12 | 4-1 | ||
| Fri, Oct 1, 2010 | St. Xavier | W | 48–0 | 5-1 | |||
| Fri, Oct 8, 2010 | Seneca | away | W | 63–14 | 6-1 | ||
| Fri, Oct 15, 2010 | Eastern | away | W | 49–0 | 7-1 | ||
| Fri, Oct 22, 2010 | Ballard | home | W | 56–21 | 8-1 | ||
| Fri, Oct 29, 2010 | Lexington Catholic | home | W | 56–7 | 9-1 | ||
| Fri, Nov 5, 2010 | Pleasure Ridge Park | home | W | 55–6 | 10-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | DuPont Manual | home | W | 48–13 | 11-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | St. Xavier | at pjcs | W | 35–7 | 12-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Ryle | away | W | 28–9 | 13-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Sat, Dec 4, 2010 | Male | at houchens-l.t. smith stadium, wku | W | 38–0 | 14-1 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |