Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Whitley County | away | W | 46–27 | 1-0 | ||
| Sat, Aug 28, 2010 | Covington Catholic | home | L | 21–54 | 1-1 | ||
| Fri, Sep 3, 2010 | St. Xavier | away | L | 0–37 | 1-2 | ||
| Fri, Sep 10, 2010 | Lone Oak | home | L | 25–33 | 1-3 | ||
| Fri, Sep 17, 2010 | Madison Central | home | W | 21–14 | 2-3 | ||
| Fri, Sep 24, 2010 | Lexington Christian | home | W | 62–0 | 3-3 | ||
| Fri, Oct 8, 2010 | Boyle County | home | L | 10–42 | 3-4 | ||
| Thu, Oct 14, 2010 | East Jessamine | away | W | 46–40 | 4-4 | ||
| Fri, Oct 22, 2010 | West Jessamine | away | W | 42–26 | 5-4 | ||
| Fri, Oct 29, 2010 | Trinity (Louisville) | away | L | 7–56 | 5-5 | ||
| Fri, Nov 5, 2010 | Harrison County | home | W | 27–19 | 6-5 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | West Jessamine | home | W | 41–14 | 7-5 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Boyle County | away | L | 35–45 | 7-6 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl |