Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Christ Presbyterian Academy, TN | home | L | 12–20 | 0-1 | ||
| Fri, Sep 3, 2010 | Lynn Camp | away | W | 43–20 | 1-1 | ||
| Fri, Sep 10, 2010 | Christian Academy-Louisville | home | W | 20–14 | 2-1 | overtime | |
| Fri, Sep 17, 2010 | Breathitt County | away | W | 30–15 | 3-1 | ||
| Fri, Sep 24, 2010 | Lexington Catholic | away | L | 0–62 | 3-2 | ||
| Fri, Oct 1, 2010 | Nicholas County | home | W | 34–13 | 4-2 | ||
| Fri, Oct 8, 2010 | Paris | away | W | 55–7 | 5-2 | ||
| Fri, Oct 15, 2010 | Raceland | away | W | 38–26 | 6-2 | ||
| Fri, Oct 22, 2010 | Fairview | home | W | 41–21 | 7-2 | ||
| Fri, Oct 29, 2010 | Corbin | away | L | 22–29 | 7-3 | ||
| Fri, Nov 5, 2010 | Berea | home | W | 50–20 | 8-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Raceland | home | W | 48–8 | 9-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Fairview | home | W | 23–12 | 10-3 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Hazard | away | L | 30–31 | 10-4 | 2010 Class 1A KHSAA Commonwealth Gridiron Bowl |