Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Harlan | home | W | 52–14 | 1-0 | ||
| Sat, Sep 4, 2010 | Boyle County | home | L | 10–42 | 1-1 | ||
| Fri, Sep 10, 2010 | North Laurel | away | W | 24–6 | 2-1 | ||
| Fri, Sep 17, 2010 | South Laurel | home | W | 21–0 | 3-1 | ||
| Fri, Sep 24, 2010 | Hazard | away | L | 28–35 | 3-2 | ||
| Fri, Oct 1, 2010 | George Rogers Clark | home | W | 21–7 | 4-2 | ||
| Thu, Oct 7, 2010 | Knott County Central | home | W | 71–6 | 5-2 | ||
| Fri, Oct 15, 2010 | Leslie County | away | W | 49–0 | 6-2 | ||
| Fri, Oct 22, 2010 | Middlesboro | away | W | 40–13 | 7-2 | ||
| Fri, Oct 29, 2010 | Lexington Christian | home | W | 29–22 | 8-2 | ||
| Fri, Nov 5, 2010 | Bath County | home | W | 55–8 | 9-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Leslie County | home | W | 52–21 | 10-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Prestonsburg | home | W | 48–14 | 11-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Newport Central Catholic | home | L | 8–42 | 11-3 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl |