Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Bryan Station | home | W | 46–18 | 1-0 | ||
| Fri, Sep 3, 2010 | Montgomery County | away | W | 41–19 | 2-0 | ||
| Fri, Sep 10, 2010 | Paul Laurence Dunbar | home | W | 49–21 | 3-0 | ||
| Fri, Sep 17, 2010 | Lafayette | L | 9–21 | 3-1 | |||
| Fri, Sep 24, 2010 | Scott County | home | L | 15–25 | 3-2 | ||
| Fri, Oct 1, 2010 | Corbin | away | L | 7–21 | 3-3 | ||
| Fri, Oct 8, 2010 | Henry Clay | home | L | 35–54 | 3-4 | ||
| Fri, Oct 15, 2010 | Tates Creek | away | W | 27–12 | 4-4 | ||
| Fri, Oct 22, 2010 | Madison Central | home | W | 35–14 | 5-4 | ||
| Fri, Oct 29, 2010 | Campbell County | away | L | 42–45 | 5-5 | (double overtime) | |
| Fri, Nov 5, 2010 | Campbell County | home | L | 34–35 | 5-6 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |