Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Clay County | home | L | 26–41 | 0-1 | ||
| Fri, Sep 3, 2010 | Boone County | home | L | 6–17 | 0-2 | ||
| Fri, Sep 10, 2010 | Henry Clay | home | L | 20–31 | 0-3 | ||
| Fri, Sep 17, 2010 | Oldham County | home | W | 40–14 | 1-3 | ||
| Fri, Sep 24, 2010 | George Rogers Clark | away | W | 25–15 | 2-3 | ||
| Fri, Oct 1, 2010 | Tates Creek | away | W | 25–7 | 3-3 | ||
| Fri, Oct 8, 2010 | Bryan Station | home | W | 46–26 | 4-3 | ||
| Fri, Oct 15, 2010 | Paul Laurence Dunbar | home | W | 53–7 | 5-3 | ||
| Fri, Oct 22, 2010 | Lafayette | away | W | 47–20 | 6-3 | ||
| Fri, Oct 29, 2010 | Fern Creek | away | W | 49–0 | 7-3 | ||
| Fri, Nov 5, 2010 | Nelson County | home | W | 41–0 | 8-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Central Hardin | home | W | 35–7 | 9-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Lafayette | home | W | 42–28 | 10-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Male | home | L | 12–28 | 10-4 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |