Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | — | home | W | 33– | 1-0 | ||
| Fri, Aug 27, 2010 | Eastern | home | W | 35–28 | 2-0 | ||
| Fri, Sep 3, 2010 | Western | away | W | 17–16 | 3-0 | overtime | |
| Fri, Sep 10, 2010 | Central | away | W | 36–0 | 4-0 | ||
| Fri, Sep 17, 2010 | St. Xavier | home | L | 7–14 | 4-1 | ||
| Fri, Sep 24, 2010 | Ballard | away | W | 26–20 | 5-1 | ||
| Fri, Oct 1, 2010 | Dunbar (Dayton), OH | home | L | 13–19 | 5-2 | ||
| Thu, Oct 14, 2010 | Southern | home | W | 50–6 | 6-2 | ||
| Fri, Oct 22, 2010 | Fern Creek | home | W | 38–23 | 7-2 | ||
| Fri, Oct 29, 2010 | DuPont Manual | home | L | 14–21 | 7-3 | ||
| Fri, Nov 5, 2010 | Apollo | home | W | 52–0 | 8-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Graves County | home | W | 42–20 | 9-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Henderson County | home | W | 14–7 | 10-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Scott County | away | W | 28–12 | 11-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Sat, Dec 4, 2010 | Trinity (Louisville) | at houchens-l.t. smith stadium, wku | L | 0–38 | 11-4 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |
