Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Pleasure Ridge Park | home | W | 59–7 | 1-0 | ||
| Fri, Aug 27, 2010 | St. Xavier | away | L | 34–35 | 1-1 | ||
| Fri, Sep 3, 2010 | Central | home | W | 42–14 | 2-1 | ||
| Fri, Sep 10, 2010 | Madison Central | away | W | 49–6 | 3-1 | ||
| Fri, Sep 17, 2010 | Meade County | home | W | 45–10 | 4-1 | ||
| Fri, Sep 24, 2010 | Male | home | L | 20–26 | 4-2 | ||
| Fri, Oct 8, 2010 | Eastern | away | W | 38–21 | 5-2 | ||
| Fri, Oct 15, 2010 | Seneca | home | W | 27–21 | 6-2 | ||
| Fri, Oct 22, 2010 | Trinity (Louisville) | away | L | 21–56 | 6-3 | ||
| Fri, Oct 29, 2010 | Western | away | W | 25–23 | 7-3 | ||
| Fri, Nov 5, 2010 | Butler | home | W | 42–12 | 8-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | St. Xavier | away | L | 21–42 | 8-4 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |
