Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Central | home | W | 47–32 | 1-0 | ||
| Fri, Aug 27, 2010 | Southern | away | W | 49–21 | 2-0 | ||
| Fri, Sep 3, 2010 | Fern Creek | home | W | 29–26 | 3-0 | ||
| Fri, Sep 10, 2010 | Wayne (Huber Heights), OH | away | L | 7–31 | 3-1 | ||
| Fri, Sep 17, 2010 | DeSales | at dupont manual | W | 40–34 | 4-1 | overtime | |
| Fri, Sep 24, 2010 | DuPont Manual | away | L | 32–46 | 4-2 | ||
| Thu, Sep 30, 2010 | Butler | home | W | 56–17 | 5-2 | ||
| Fri, Oct 8, 2010 | Trinity (Louisville) | home | L | 14–63 | 5-3 | ||
| Fri, Oct 15, 2010 | Ballard | away | L | 21–27 | 5-4 | ||
| Fri, Oct 22, 2010 | Eastern | home | L | 47–50 | 5-5 | ||
| Fri, Nov 5, 2010 | St. Xavier | away | L | 33–48 | 5-6 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |