Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Ballard | home | W | 35–34 | 1-0 | ||
| Fri, Sep 3, 2010 | Lexington Catholic | home | W | 37–0 | 2-0 | ||
| Fri, Sep 10, 2010 | Cincinnati St. Xavier, OH | away | L | 13–32 | 2-1 | ||
| Fri, Sep 17, 2010 | Male | away | W | 14–7 | 3-1 | ||
| Fri, Sep 24, 2010 | Central | home | W | 35–20 | 4-1 | ||
| Fri, Oct 1, 2010 | Trinity (Louisville) | L | 0–48 | 4-2 | |||
| Fri, Oct 8, 2010 | Butler | away | W | 51–7 | 5-2 | ||
| Fri, Oct 15, 2010 | DuPont Manual | home | W | 38–7 | 6-2 | ||
| Fri, Oct 22, 2010 | Pleasure Ridge Park | away | W | 27–21 | 7-2 | ||
| Sat, Oct 30, 2010 | Covington Catholic | away | W | 40–19 | 8-2 | ||
| Fri, Nov 5, 2010 | Seneca | home | W | 48–33 | 9-2 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Ballard | home | W | 42–21 | 10-2 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Trinity (Louisville) | at pjcs | L | 7–35 | 10-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |