Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Western | at dupont manual | L | 10–17 | 0-1 | ||
| Fri, Aug 27, 2010 | Elizabethtown | at central hardin | W | 28–6 | 1-1 | ||
| Fri, Sep 3, 2010 | Bullitt East | away | W | 21–0 | 2-1 | ||
| Fri, Sep 10, 2010 | Holy Cross (Louisville) | away | L | 0–12 | 2-2 | ||
| Fri, Sep 17, 2010 | Seneca | at dupont manual | L | 34–40 | 2-3 | overtime | |
| Fri, Oct 1, 2010 | Fern Creek | away | L | 21–26 | 2-4 | ||
| Fri, Oct 8, 2010 | Owen County | away | W | 45–13 | 3-4 | ||
| Fri, Oct 15, 2010 | Christian Academy-Louisville | at dupont manual | W | 31–26 | 4-4 | ||
| Fri, Oct 22, 2010 | Carroll County | at dupont manual | W | 50–6 | 5-4 | ||
| Fri, Oct 29, 2010 | Southern | at dupont manual | W | 17–7 | 6-4 | ||
| Fri, Nov 5, 2010 | Lloyd Memorial | home | W | 51–6 | 7-4 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Holy Cross (Covington) | home | L | 14–26 | 7-5 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl |