Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | DuPont Manual | away | L | 14–59 | 0-1 | ||
| Fri, Sep 3, 2010 | Seneca | away | L | 26–29 | 0-2 | ||
| Fri, Sep 10, 2010 | Meade County | home | W | 46–21 | 1-2 | ||
| Fri, Sep 17, 2010 | Eastern | home | L | 20–60 | 1-3 | ||
| Fri, Sep 24, 2010 | Franklin, TN | away | L | 6–34 | 1-4 | ||
| Fri, Oct 1, 2010 | DeSales | home | W | 26–21 | 2-4 | ||
| Fri, Oct 8, 2010 | Southern | away | W | 39–14 | 3-4 | ||
| Fri, Oct 15, 2010 | Collins | away | L | 14–34 | 3-5 | ||
| Fri, Oct 22, 2010 | Male | away | L | 23–38 | 3-6 | ||
| Fri, Oct 29, 2010 | Scott County | home | L | 0–49 | 3-7 | ||
| Fri, Nov 5, 2010 | Marshall County | home | W | 25–6 | 4-7 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Henderson County | away | L | 35–56 | 4-8 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |
