Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Boone County | home | L | 19–28 | 0-1 | ||
| Fri, Sep 3, 2010 | Pulaski County | away | W | 35–28 | 1-1 | overtime | |
| Fri, Sep 10, 2010 | Scott County | away | W | 31–20 | 2-1 | ||
| Fri, Sep 17, 2010 | Simon Kenton | home | L | 18–21 | 2-2 | ||
| Fri, Sep 24, 2010 | Lafayette | W | 27–20 | 3-2 | |||
| Fri, Oct 1, 2010 | Bryan Station | away | W | 49–8 | 4-2 | ||
| Fri, Oct 8, 2010 | George Rogers Clark | away | W | 54–35 | 5-2 | ||
| Fri, Oct 15, 2010 | Madison Central | home | W | 70–30 | 6-2 | ||
| Fri, Oct 22, 2010 | Tates Creek | home | W | 85–52 | 7-2 | ||
| Fri, Oct 29, 2010 | Paul Laurence Dunbar | away | W | 41–5 | 8-2 | ||
| Fri, Nov 5, 2010 | Conner | home | W | 32–20 | 9-2 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Simon Kenton | home | L | 19–21 | 9-3 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |
