Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Norwood, OH | away | W | 50–7 | 1-0 | ||
| Fri, Sep 3, 2010 | Roger Bacon, OH | away | L | 7–20 | 1-1 | ||
| Sat, Sep 11, 2010 | Covington Catholic | away | L | 14–49 | 1-2 | ||
| Fri, Sep 17, 2010 | Newport Central Catholic | home | L | 23–26 | 1-3 | ||
| Fri, Sep 24, 2010 | Boone County | home | W | 29–20 | 2-3 | ||
| Fri, Oct 1, 2010 | Ryle | away | L | 30–35 | 2-4 | ||
| Fri, Oct 8, 2010 | Conner | home | W | 14–13 | 3-4 | ||
| Fri, Oct 15, 2010 | Cooper | home | W | 35–28 | 4-4 | overtime | |
| Fri, Oct 22, 2010 | Simon Kenton | away | L | 12–50 | 4-5 | ||
| Fri, Oct 29, 2010 | George Rogers Clark | home | W | 45–42 | 5-5 | (double overtime) | |
| Fri, Nov 5, 2010 | George Rogers Clark | away | W | 35–34 | 6-5 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Ryle | away | L | 14–38 | 6-6 | 2010 Class 6A KHSAA Commonwealth Gridiron Bowl |
