Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Ballard Memorial | away | W | 49–27 | 1-0 | ||
| Fri, Aug 27, 2010 | Reidland | home | W | 54–21 | 2-0 | ||
| Fri, Sep 3, 2010 | Marshall County | away | W | 29–6 | 3-0 | ||
| Fri, Sep 10, 2010 | Lexington Catholic | away | W | 33–25 | 4-0 | ||
| Fri, Sep 17, 2010 | Caldwell County | away | W | 52–8 | 5-0 | ||
| Fri, Sep 24, 2010 | Graves County | home | W | 19–6 | 6-0 | ||
| Fri, Oct 1, 2010 | Green County | away | L | 17–20 | 6-1 | ||
| Fri, Oct 8, 2010 | Calloway County | home | W | 63–28 | 7-1 | ||
| Fri, Oct 15, 2010 | Hopkins County Central | home | W | 47–12 | 8-1 | ||
| Fri, Oct 29, 2010 | Heath | home | W | 70–18 | 9-1 | ||
| Fri, Nov 5, 2010 | Warren East | home | W | 43–7 | 10-1 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Franklin-Simpson | home | W | 35–32 | 11-1 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Allen County-Scottsville | away | L | 28–35 | 11-2 | 2010 Class 4A KHSAA Commonwealth Gridiron Bowl |