Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | McLean County | home | W | 49–6 | 1-0 | ||
| Fri, Aug 27, 2010 | Warren East | at kwc steel stadium/rash stadium | W | 56–14 | 2-0 | ||
| Fri, Sep 3, 2010 | Owensboro | home | L | 13–35 | 2-1 | ||
| Fri, Sep 10, 2010 | South Spencer, IN | away | W | 63–21 | 3-1 | ||
| Fri, Sep 17, 2010 | Apollo | away | W | 28–7 | 4-1 | ||
| Fri, Sep 24, 2010 | Henry County | home | W | 49–13 | 5-1 | ||
| Fri, Oct 8, 2010 | Hancock County | home | W | 37–20 | 6-1 | ||
| Fri, Oct 15, 2010 | Todd County Central | home | W | 61–14 | 7-1 | ||
| Fri, Oct 22, 2010 | Fort Campbell | away | W | 34–0 | 8-1 | ||
| Fri, Oct 29, 2010 | Daviess County | away | W | 38–16 | 9-1 | ||
| Fri, Nov 5, 2010 | Reidland | home | W | 54–7 | 10-1 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Caldwell County | home | W | 43–14 | 11-1 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Murray | home | W | 29–22 | 12-1 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Danville | away | W | 61–42 | 13-1 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Dec 3, 2010 | Newport Central Catholic | at houchens-l.t. smith stadium, wku | L | 0–42 | 13-2 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl |