Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Holy Cross (Louisville) | home | L | 24–54 | 0-1 | ||
| Fri, Aug 27, 2010 | South Oldham | away | W | 27–20 | 1-1 | ||
| Fri, Sep 3, 2010 | Trimble County | home | W | 44–6 | 2-1 | ||
| Fri, Sep 10, 2010 | Owen County | away | W | 54–12 | 3-1 | ||
| Fri, Sep 17, 2010 | Anderson County | away | W | 45–42 | 4-1 | ||
| Fri, Sep 24, 2010 | Owensboro Catholic | away | L | 13–49 | 4-2 | ||
| Fri, Oct 8, 2010 | North Oldham | home | L | 9–24 | 4-3 | ||
| Fri, Oct 15, 2010 | Western Hills | away | W | 61–33 | 5-3 | ||
| Fri, Oct 22, 2010 | Spencer County | home | W | 41–8 | 6-3 | ||
| Fri, Oct 29, 2010 | Gallatin County | away | W | 61–6 | 7-3 | ||
| Fri, Nov 5, 2010 | Moore | home | L | 14–20 | 7-4 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl |