Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 27, 2010 | Bellevue | away | L | 34–35 | 0-1 | ||
| Fri, Sep 3, 2010 | Pendleton County | away | W | 49–6 | 1-1 | ||
| Fri, Sep 10, 2010 | Harrison County | away | L | 14–21 | 1-2 | ||
| Fri, Sep 17, 2010 | Dayton | home | W | 62–0 | 2-2 | ||
| Fri, Sep 24, 2010 | Estill County | away | W | 42–22 | 3-2 | ||
| Fri, Oct 1, 2010 | Newport Central Catholic | home | L | 13–54 | 3-3 | ||
| Fri, Oct 8, 2010 | Lloyd Memorial | home | W | 29–13 | 4-3 | ||
| Fri, Oct 15, 2010 | Fleming County | home | W | 45–0 | 5-3 | ||
| Sat, Oct 23, 2010 | Holy Cross (Covington) | away | L | 21–55 | 5-4 | ||
| Fri, Oct 29, 2010 | Cooper | home | L | 19–26 | 5-5 | ||
| Fri, Nov 5, 2010 | Christian Academy-Louisville | away | L | 21–30 | 5-6 | 2010 Class 2A KHSAA Commonwealth Gridiron Bowl |