Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 27, 2000 | Muhlenberg South | away | L | 44–59 | 0-1 | ||
| Thu, Nov 30, 2000 | Grayson County | away | W | 48–34 | 1-1 | ||
| Mon, Dec 4, 2000 | Owensboro | away | W | 28–27 | 2-1 | ||
| Thu, Dec 7, 2000 | Hancock County | home | W | 66–36 | 3-1 | ||
| Mon, Dec 11, 2000 | Madisonville-North Hopkins | home | L | 37–47 | 3-2 | ||
| Mon, Dec 18, 2000 | Owensboro Catholic | away | W | 44–41 | 4-2 | Independence Bank Lady Classic | |
| Tue, Dec 19, 2000 | Pleasure Ridge Park | at owensboro catholic | L | 45–50 | 4-3 | Independence Bank Classic | |
| Wed, Dec 20, 2000 | McLean County | at owensboro catholic | W | 41–31 | 5-3 | Independence Bank Classic | |
| Thu, Dec 28, 2000 | Marshall County | away | L | 45–65 | 5-4 | Firstar Holiday Classic | |
| Fri, Dec 29, 2000 | Moore | at marshall county | L | 43–58 | 5-5 | Firstar Holiday Classic | |
| Sat, Dec 30, 2000 | Kirby, TN | at marshall county | L | 41–56 | 5-6 | Firstar Holiday Classic | |
| Fri, Jan 5, 2001 | Daviess County | away | L | 35–45 | 5-7 | ||
| Mon, Jan 8, 2001 | Owensboro Catholic | home | W | 50–36 | 6-7 | ||
| Thu, Jan 11, 2001 | McLean County | away | W | 52–31 | 7-7 | ||
| Sat, Jan 13, 2001 | Union County | away | L | 49–65 | 7-8 | ||
| Thu, Jan 18, 2001 | Breckinridge County | away | W | 52–38 | 8-8 | ||
| Mon, Jan 22, 2001 | Owensboro | home | W | 59–43 | 9-8 | ||
| Thu, Jan 25, 2001 | Daviess County | home | W | 54–33 | 10-8 | ||
| Thu, Feb 1, 2001 | Henderson County | away | L | 38–64 | 10-9 | ||
| Mon, Feb 5, 2001 | Ohio County | home | L | 49–59 | 10-10 | ||
| Thu, Feb 8, 2001 | Owensboro Catholic | away | W | 47–43 | 11-10 | ||
| Mon, Feb 12, 2001 | Muhlenberg North | home | L | 48–72 | 11-11 | ||
| Thu, Feb 15, 2001 | Warren Central | away | L | 41–42 | 11-12 | ||
| Mon, Feb 19, 2001 | Warren East | home | L | 56–60 | 11-13 | ||
| Thu, Feb 22, 2001 | Butler County | home | L | 48–58 | 11-14 | ||
| Mon, Feb 26, 2001 | Owensboro | away | W | 47–32 | 12-14 | 2001 9th District Girls Basketball Tournament | |
| Thu, Mar 1, 2001 | Owensboro Catholic | at owensboro | L | 36–43 | 12-15 | 2001 9th District Girls Basketball Tournament | |
| Wed, Mar 7, 2001 | Breckinridge County | at hancock county | W | 50–46 | 13-15 | 2001 3rd Region Girls Basketball Tournament | |
| Mon, Mar 12, 2001 | Muhlenberg North | at hancock county | L | 42–60 | 13-16 | 2001 3rd Region Girls Basketball Tournament |