Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Tue, Nov 28, 2000 | Sacred Heart | away | L | 43–87 | 0-1 | ||
| Thu, Nov 30, 2000 | Central Hardin | home | L | 38–73 | 0-2 | ||
| Tue, Dec 5, 2000 | Fairdale | home | W | 64–43 | 1-2 | ||
| Fri, Dec 8, 2000 | Butler | home | L | 55–79 | 1-3 | ||
| Tue, Dec 12, 2000 | Holy Rosary | home | L | 58–71 | 1-4 | ||
| Mon, Dec 18, 2000 | Owensboro | at owensboro catholic | W | 72–58 | 2-4 | Independence Bank Lady Classic | |
| Tue, Dec 19, 2000 | Apollo | at owensboro catholic | W | 50–45 | 3-4 | Independence Bank Classic | |
| Wed, Dec 20, 2000 | Owensboro Catholic | away | W | 51–46 | 4-4 | Independence Bank Classic | |
| Wed, Dec 27, 2000 | Pike County Central | at johnson central | L | 65–68 | 4-5 | Lady Eagle Holiday Classic | |
| Thu, Dec 28, 2000 | Cumberland | at johnson central | W | 69–45 | 5-5 | Lady Eagle Holiday Classic | |
| Fri, Dec 29, 2000 | Johnson Central | away | L | 60–70 | 5-6 | Lady Eagle Holiday Classic | |
| Sat, Dec 30, 2000 | Lawrence County | at johnson central | W | 73–52 | 6-6 | Lady Eagle Holiday Classic | |
| Tue, Jan 2, 2001 | Presentation | at spalding university | L | 57–68 | 6-7 | ||
| Fri, Jan 5, 2001 | Valley | away | W | 57–56 | 7-7 | ||
| Tue, Jan 9, 2001 | Holy Cross (Louisville) | home | W | 53–50 | 8-7 | ||
| Thu, Jan 11, 2001 | Ballard | home | W | 65–46 | 9-7 | ||
| Tue, Jan 16, 2001 | Doss | away | W | 69–50 | 10-7 | ||
| Fri, Jan 19, 2001 | Shawnee | away | |||||
| Sat, Jan 20, 2001 | Oldham County | at trinity (louisville) | L | 43–68 | 10-8 | Kentucky Preps Plus Classic | |
| Thu, Jan 25, 2001 | Eastern | home | W | 66–62 | 11-8 | ||
| Tue, Jan 30, 2001 | Central | home | L | 68–69 | 11-9 | ||
| Fri, Feb 2, 2001 | Western | home | W | 81–49 | 12-9 | ||
| Tue, Feb 6, 2001 | Southern | away | W | 72–42 | 13-9 | ||
| Fri, Feb 9, 2001 | Iroquois | home | W | 91–60 | 14-9 | ||
| Fri, Feb 16, 2001 | Bullitt East | away | W | 90–86 | 15-9 | ||
| Tue, Feb 20, 2001 | Jeffersontown | away | L | 72–74 | 15-10 | (overtime) | |
| Fri, Feb 23, 2001 | Christian Academy-Louisville | home | W | 65–61 | 16-10 | ||
| Wed, Feb 28, 2001 | Holy Cross (Louisville) | home | L | 43–45 | 16-11 | 2001 22nd District Girls Basketball Tournament |