Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 27, 2000 | Breckinridge County | away | W | 64–55 | 1-0 | ||
| Thu, Nov 30, 2000 | Owensboro | home | W | 53–36 | 2-0 | ||
| Mon, Dec 4, 2000 | Butler County | away | L | 37–53 | 2-1 | ||
| Thu, Dec 7, 2000 | Grayson County | away | W | 56–52 | 3-1 | ||
| Mon, Dec 11, 2000 | Trinity (Whitesville) | away | W | 61–54 | 4-1 | ||
| Sat, Dec 16, 2000 | Owensboro Catholic | home | W | 53–49 | 5-1 | ||
| Wed, Dec 27, 2000 | North Laurel | home | L | 55–67 | 5-2 | Lady Panther Invitational | |
| Thu, Dec 28, 2000 | Paducah Tilghman | home | W | 87–44 | 6-2 | Lady Panther Invitational | |
| Tue, Jan 2, 2001 | Meade County | home | W | 54–46 | 7-2 | Lady Panther Invitational (championship) | |
| Fri, Jan 5, 2001 | Apollo | home | W | 45–35 | 8-2 | ||
| Tue, Jan 9, 2001 | Owensboro | away | L | 56–63 | 8-3 | ||
| Thu, Jan 11, 2001 | Owensboro Catholic | away | L | 44–52 | 8-4 | ||
| Tue, Jan 16, 2001 | Henderson County | home | L | 44–79 | 8-5 | ||
| Mon, Jan 22, 2001 | McLean County | home | W | 53–50 | 9-5 | ||
| Thu, Jan 25, 2001 | Apollo | away | L | 33–54 | 9-6 | ||
| Mon, Jan 29, 2001 | Madisonville-North Hopkins | away | L | 40–56 | 9-7 | ||
| Thu, Feb 1, 2001 | Hancock County | home | W | 51–25 | 10-7 | ||
| Fri, Feb 2, 2001 | Ohio County | away | L | 54–66 | 10-8 | ||
| Tue, Feb 6, 2001 | Muhlenberg South | home | L | 42–56 | 10-9 | ||
| Thu, Feb 8, 2001 | McLean County | away | W | 53–46 | 11-9 | ||
| Mon, Feb 12, 2001 | Butler County | home | L | 47–72 | 11-10 | ||
| Thu, Feb 15, 2001 | Cloverport | at frederick fraize | W | 40–39 | 12-10 | ||
| Mon, Feb 19, 2001 | Muhlenberg North | home | L | 53–94 | 12-11 | ||
| Thu, Feb 22, 2001 | Trinity (Whitesville) | home | L | 63–67 | 12-12 | ||
| Mon, Feb 26, 2001 | Owensboro Catholic | at owensboro | L | 42–53 | 12-13 | 2001 9th District Girls Basketball Tournament |