Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 29, 2021 | Pleasure Ridge Park | home | W | 63–50 | 1-0 | ||
| Thu, Dec 2, 2021 | Louisville Collegiate | home | W | 57–15 | 2-0 | ||
| Sat, Dec 4, 2021 | Hancock County | away | W | 64–37 | 3-0 | ||
| Thu, Dec 9, 2021 | Oldham County | away | W | 55–41 | 4-0 | ||
| Fri, Dec 10, 2021 | Jeffersontown | away | W | 54–22 | 5-0 | ||
| Mon, Dec 13, 2021 | Kentucky Country Day | home | W | 55–15 | 6-0 | ||
| Tue, Dec 14, 2021 | Bullitt East | home | L | 28–53 | 6-1 | ||
| Thu, Dec 16, 2021 | Brown | away | W | 39–10 | 7-1 | ||
| Fri, Dec 17, 2021 | Danville Christian | home | L | 46–50 | 7-2 | ||
| Mon, Dec 20, 2021 | Paintsville | at gatlinburg, tenn. | W | 51–24 | 8-2 | ||
| Tue, Dec 21, 2021 | Walton-Verona | at gatlinburg, tenn. | W | 42–36 | 9-2 | ||
| Wed, Dec 22, 2021 | Baylor (Chattanooga), TN | at gatlinburg, tenn. | L | 26–36 | 9-3 | ||
| Tue, Dec 28, 2021 | South Central (Elizabeth), IN | home | W | 77–23 | 10-3 | ||
| Wed, Dec 29, 2021 | Prestonsburg | home | W | 51–21 | 11-3 | ||
| Tue, Jan 4, 2022 | Mercy Academy | home | L | 37–56 | 11-4 | ||
| Mon, Jan 10, 2022 | Louisville Collegiate | at whitefield academy/cal | W | 49–11 | 12-4 | ||
| Thu, Jan 13, 2022 | Kentucky Country Day | at whitefield academy/cal | W | 70–11 | 13-4 | 7th Region All "A" Classic | |
| Fri, Jan 14, 2022 | Fairdale | home | W | 77–4 | 14-4 | ||
| Sat, Jan 15, 2022 | Eastern | away | L | 46–55 | 14-5 | (overtime) | |
| Sat, Jan 22, 2022 | Christian Fellowship | at various sites | W | 74–62 | 15-5 | KCAC Tournament | |
| Sat, Jan 22, 2022 | Heritage (Hopkinsville) | at various sites | W | 60–4 | 16-5 | ||
| Wed, Jan 26, 2022 | Holy Cross (Louisville) | at eku mcbrayer arena | W | 51–44 | 17-5 | (overtime) | |
| Fri, Jan 28, 2022 | Owensboro Catholic | at eku mcbrayer arena | L | 29–41 | 17-6 | All A State Tournament | |
| Tue, Feb 1, 2022 | North Bullitt | home | W | 56–38 | 18-6 | ||
| Sat, Feb 5, 2022 | Madison Southern | away | L | 42–47 | 18-7 | ||
| Tue, Feb 8, 2022 | North Oldham | away | W | 53–37 | 19-7 | ||
| Thu, Feb 10, 2022 | John Hardin | away | W | 58–54 | 20-7 | (overtime) | |
| Fri, Feb 11, 2022 | Presentation | home | W | 46–35 | 21-7 | ||
| Sat, Feb 12, 2022 | Holy Cross (Louisville) | away | W | 37–29 | 22-7 | ||
| Fri, Feb 18, 2022 | Butler | away | W | 52–47 | 23-7 | ||
| Mon, Feb 21, 2022 | Bullitt East | at fern creek | L | 39–53 | 23-8 | 2022 24th District Girls Basketball Tournament |