Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Wed, Dec 1, 2021 | Male | at mercy | L | 64–74 | 0-1 | ||
| Fri, Dec 3, 2021 | Breckinridge County | away | L | 53–55 | 0-2 | ||
| Tue, Dec 7, 2021 | DuPont Manual | at mercy | W | 75–62 | 1-2 | ||
| Fri, Dec 10, 2021 | Fern Creek | at mercy | W | 62–23 | 2-2 | ||
| Sat, Dec 11, 2021 | North Oldham | away | W | 84–44 | 3-2 | ||
| Sat, Dec 18, 2021 | Paul Laurence Dunbar | at lexington catholic | W | 75–49 | 4-2 | Traditional Bank Holiday Classic | |
| Sun, Dec 19, 2021 | Shelby Valley | at lexington catholic | W | 70–55 | 5-2 | Traditional Bank Holiday Classic | |
| Mon, Dec 20, 2021 | George Rogers Clark | at lexington catholic | L | 59–77 | 5-3 | ||
| Tue, Dec 21, 2021 | Cooper | at lexington catholic | W | 51–40 | 6-3 | ||
| Mon, Dec 27, 2021 | Walton-Verona | at anderson county | W | 89–46 | 7-3 | ||
| Tue, Dec 28, 2021 | Cooper | at anderson county | L | 55–59 | 7-4 | ||
| Wed, Dec 29, 2021 | Owen County | at anderson county | W | 84–59 | 8-4 | ||
| Tue, Jan 4, 2022 | Whitefield Academy | away | W | 56–37 | 9-4 | ||
| Mon, Jan 10, 2022 | Pleasure Ridge Park | away | W | 84–54 | 10-4 | ||
| Tue, Jan 11, 2022 | Notre Dame | away | L | 54–66 | 10-5 | ||
| Fri, Jan 14, 2022 | Butler | away | W | 55–46 | 11-5 | ||
| Thu, Jan 20, 2022 | Bullitt East | at mercy | W | 64–50 | 12-5 | ||
| Sat, Jan 22, 2022 | Central | at mercy | W | 65–59 | 13-5 | ||
| Tue, Jan 25, 2022 | Pleasure Ridge Park | at valley | W | 60–40 | 14-5 | ||
| Sat, Jan 29, 2022 | Male | at various sites | W | 81–71 | 15-5 | Republic Bank Louisville Invitational Tourn… | |
| Sun, Jan 30, 2022 | Sacred Heart | at various sites | L | 52–75 | 15-6 | Republic Bank Louisville Invitational Tourn… | |
| Mon, Jan 31, 2022 | Assumption | at mercy | W | 63–42 | 16-6 | ||
| Tue, Feb 8, 2022 | Bardstown | at mercy | W | 77–75 | 17-6 | (overtime) | |
| Fri, Feb 11, 2022 | Bethlehem | away | L | 60–65 | 17-7 | ||
| Sun, Feb 13, 2022 | Sacred Heart | at mercy | W | 98–96 | 18-7 | (double overtime) | |
| Mon, Feb 14, 2022 | Holy Cross (Covington) | at mercy | W | 65–60 | 19-7 | ||
| Thu, Feb 17, 2022 | Bowling Green | at mercy | W | 73–62 | 20-7 | ||
| Mon, Feb 21, 2022 | Fern Creek | away | W | 73–21 | 21-7 | 2022 24th District Girls Basketball Tournament | |
| Wed, Feb 23, 2022 | Bullitt East | at fern creek | L | 55–60 | 21-8 | 2022 24th District Girls Basketball Tournament | |
| Mon, Feb 28, 2022 | Butler | away | W | 60–35 | 22-8 | 2022 6th Region Girls Basketball Tournament | |
| Thu, Mar 3, 2022 | Pleasure Ridge Park | at valley | W | 75–44 | 23-8 | 2022 6th Region Girls Basketball Tournament | |
| Sat, Mar 5, 2022 | Bullitt East | at valley | L | 50–63 | 23-9 | 2022 6th Region Girls Basketball Tournament |