Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 29, 2021 | Anderson County | away | L | 54–87 | 0-1 | ||
| Wed, Dec 1, 2021 | Mercy Academy | at mercy | W | 74–64 | 1-1 | ||
| Sat, Dec 4, 2021 | Breckinridge County | at owensboro catholic | W | 52–46 | 2-1 | Independence Bank Tip-Off Classic | |
| Tue, Dec 7, 2021 | Central | away | L | 40–55 | 2-2 | ||
| Fri, Dec 10, 2021 | Butler | home | W | 63–57 | 3-2 | ||
| Tue, Dec 14, 2021 | Fern Creek | away | W | 71–22 | 4-2 | ||
| Tue, Dec 21, 2021 | South Oldham | at nelson county | W | 55–46 | 5-2 | ||
| Wed, Dec 22, 2021 | North Hardin | at nelson county | W | 62–50 | 6-2 | Lady Cardinals Classic | |
| Thu, Dec 23, 2021 | Shelby County | at nelson county | W | 62–22 | 7-2 | Lady Cardinals Classic | |
| Tue, Jan 4, 2022 | Eastern | away | W | 72–53 | 8-2 | ||
| Tue, Jan 11, 2022 | Franklin County | away | W | 51–44 | 9-2 | ||
| Fri, Jan 14, 2022 | Ballard | away | W | 60–30 | 10-2 | ||
| Sat, Jan 15, 2022 | Notre Dame | home | L | 55–63 | 10-3 | ||
| Sun, Jan 16, 2022 | Brown | home | W | 53–4 | 11-3 | ||
| Fri, Jan 21, 2022 | Assumption | home | W | 83–47 | 12-3 | ||
| Sat, Jan 22, 2022 | John Hardin | away | W | 64–46 | 13-3 | ||
| Tue, Jan 25, 2022 | Bowling Green | at valley | W | 49–48 | 14-3 | Republic Bank Louisville Invitational Tourn… | |
| Sat, Jan 29, 2022 | Mercy Academy | at various sites | L | 71–81 | 14-4 | Republic Bank Louisville Invitational Tourn… | |
| Tue, Feb 1, 2022 | Seneca | away | W | 76–3 | 15-4 | ||
| Tue, Feb 8, 2022 | Louisville Collegiate | away | W | 56–6 | 16-4 | ||
| Fri, Feb 11, 2022 | DuPont Manual | away | L | 51–65 | 16-5 | ||
| Sat, Feb 12, 2022 | Pleasure Ridge Park | home | W | 62–39 | 17-5 | ||
| Thu, Feb 17, 2022 | Henry Clay | away | W | 61–57 | 18-5 | ||
| Mon, Feb 21, 2022 | Brown | at assumption | W | 68–8 | 19-5 | 2022 26th District Girls Basketball Tournament | |
| Wed, Feb 23, 2022 | Assumption | away | W | 65–50 | 20-5 | 2022 26th District Girls Basketball Tournament | |
| Mon, Feb 28, 2022 | Ballard | home | W | 89–56 | 21-5 | 2022 7th Region Girls Basketball Tournament | |
| Wed, Mar 2, 2022 | Sacred Heart | at valley | L | 46–65 | 21-6 | 2022 7th Region Girls Basketball Tournament |