Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 29, 2021 | North Bullitt | away | L | 55–64 | 0-1 | ||
| Wed, Dec 1, 2021 | Holy Cross (Louisville) | home | W | 69–53 | 1-1 | ||
| Fri, Dec 3, 2021 | Shelby County | away | W | 53–46 | 2-1 | ||
| Tue, Dec 7, 2021 | Seneca | home | W | 78–26 | 3-1 | ||
| Fri, Dec 10, 2021 | Beechwood | home | W | 60–19 | 4-1 | ||
| Tue, Dec 14, 2021 | South Oldham | home | W | 60–58 | 5-1 | ||
| Fri, Dec 17, 2021 | Bullitt Central | home | W | 58–56 | 6-1 | ||
| Sat, Dec 18, 2021 | Anderson County | away | L | 31–57 | 6-2 | ||
| Sun, Dec 19, 2021 | Boyd County | away | L | 51–77 | 6-3 | ||
| Mon, Dec 20, 2021 | Paul Laurence Dunbar | home | W | 62–47 | 7-3 | ||
| Mon, Dec 27, 2021 | Paducah Tilghman | at caverna | L | 75–80 | 7-4 | Kysports.tv Girls Christmas Classic (overti… | |
| Tue, Dec 28, 2021 | Iroquois | at caverna | W | 79–23 | 8-4 | ||
| Wed, Dec 29, 2021 | Edmonson County | W | 58–52 | 9-4 | Kysports.tv Girls Christmas Classic (overti… | ||
| Tue, Jan 4, 2022 | Male | home | L | 53–72 | 9-5 | ||
| Wed, Jan 12, 2022 | Lafayette | home | W | 47–43 | 10-5 | ||
| Sat, Jan 15, 2022 | Whitefield Academy | home | W | 55–46 | 11-5 | (overtime) | |
| Fri, Jan 21, 2022 | Ballard | home | W | 67–54 | 12-5 | ||
| Mon, Jan 24, 2022 | Ballard | at various sites | W | 68–67 | 13-5 | ||
| Wed, Jan 26, 2022 | Bullitt East | at various sites | L | 16–55 | 13-6 | Republic Bank Louisville Invitational Tourn… | |
| Mon, Jan 31, 2022 | Bardstown | home | L | 47–54 | 13-7 | ||
| Wed, Feb 2, 2022 | Presentation | away | W | 71–43 | 14-7 | ||
| Tue, Feb 8, 2022 | Christian Academy-Louisville | home | L | 34–60 | 14-8 | ||
| Fri, Feb 11, 2022 | Waggener | home | W | 68–10 | 15-8 | ||
| Sat, Feb 12, 2022 | Collins | away | W | 60–49 | 16-8 | ||
| Mon, Feb 14, 2022 | Assumption | away | L | 50–71 | 16-9 | ||
| Thu, Feb 17, 2022 | North Oldham | away | W | 76–59 | 17-9 | ||
| Fri, Feb 18, 2022 | Central | away | L | 44–73 | 17-10 | ||
| Mon, Feb 21, 2022 | Ballard | away | L | 57–75 | 17-11 | 2022 28th District Girls Basketball Tournament |