Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 27, 2000 | Paul Laurence Dunbar | home | W | 43–39 | 1-0 | ||
| Fri, Dec 1, 2000 | South Oldham | away | W | 91–46 | 2-0 | ||
| Mon, Dec 4, 2000 | Franklin County | home | W | 80–52 | 3-0 | ||
| Sat, Dec 9, 2000 | West Carter | at bryan station | L | 53–58 | 3-1 | Lady Defender Classic | |
| Mon, Dec 11, 2000 | Western Hills | away | W | 85–24 | 4-1 | ||
| Thu, Dec 14, 2000 | Trimble County | away | W | 53–46 | 5-1 | ||
| Fri, Dec 15, 2000 | North Bullitt | away | W | 66–44 | 6-1 | ||
| Wed, Dec 20, 2000 | Eastern | at male | W | 61–41 | 7-1 | Male Holiday Classic | |
| Thu, Dec 21, 2000 | Hopkins County Central | at male | W | 71–32 | 8-1 | Male Holiday Classic | |
| Fri, Dec 22, 2000 | Butler | at male | W | 67–52 | 9-1 | Male Holiday Classic | |
| Sat, Dec 23, 2000 | Male | away | L | 56–63 | 9-2 | Male Holiday Classic (championship) | |
| Fri, Jan 5, 2001 | Anderson County | away | W | 69–40 | 10-2 | ||
| Mon, Jan 8, 2001 | Mercy Academy | home | W | 66–61 | 11-2 | ||
| Thu, Jan 11, 2001 | Bryan Station | away | W | 61–54 | 12-2 | ||
| Sat, Jan 13, 2001 | Male | home | W | 71–53 | 13-2 | ||
| Fri, Jan 19, 2001 | Grant County | home | W | 75–22 | 14-2 | ||
| Sat, Jan 20, 2001 | DuPont Manual | at trinity (louisville) | W | 73–69 | 15-2 | Kentucky Preps Plus Classic (overtime) | |
| Thu, Jan 25, 2001 | Bullitt Central | home | W | 84–39 | 16-2 | ||
| Tue, Jan 30, 2001 | — | at new albany, in | W | 70– | 17-2 | ||
| Fri, Feb 2, 2001 | Oldham County | away | W | 40–39 | 18-2 | ||
| Mon, Feb 5, 2001 | Scott County | home | W | 87–42 | 19-2 | ||
| Fri, Feb 9, 2001 | North Hardin | away | L | 52–58 | 19-3 | ||
| Tue, Feb 13, 2001 | Sacred Heart | home | W | 64–57 | 20-3 | ||
| Thu, Feb 15, 2001 | Butler | away | W | 61–46 | 21-3 | ||
| Tue, Feb 20, 2001 | Presentation | home | W | 56–40 | 22-3 | ||
| Thu, Feb 22, 2001 | Eastern | home | W | 80–64 | 23-3 | ||
| Wed, Feb 28, 2001 | Anderson County | at henry county | W | 82–44 | 24-3 | 2001 30th District Girls Basketball Tournament | |
| Fri, Mar 2, 2001 | Henry County | away | W | 84–33 | 25-3 | 2001 30th District Girls Basketball Tournament | |
| Thu, Mar 8, 2001 | North Bullitt | home | W | 77–28 | 26-3 | 2001 8th Region Girls Basketball Tournament | |
| Mon, Mar 12, 2001 | Oldham County | home | L | 47–55 | 26-4 | 2001 8th Region Girls Basketball Tournament |