Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 27, 2000 | Shelby County | away | L | 39–43 | 0-1 | ||
| Sat, Dec 2, 2000 | Oldham County | at eastern | L | 47–53 | 0-2 | Eastern Extravaganza | |
| Fri, Dec 8, 2000 | Tates Creek | at paul dunbar | W | 69–57 | 1-2 | ||
| Sat, Dec 9, 2000 | Hart County | at bryan station | W | 65–58 | 2-2 | (double overtime) Lady Defender Classic | |
| Mon, Dec 11, 2000 | Bryan Station | at paul dunbar | W | 54–53 | 3-2 | ||
| Sat, Dec 16, 2000 | St. Thomas Aquinas, FL | at coral springs. fl | W | 58–43 | 4-2 | Kruel Classic | |
| Mon, Dec 18, 2000 | Westbury Christian Academy | at coral springs, fl | W | 68–48 | 5-2 | Kruel Classic | |
| Tue, Dec 19, 2000 | Graves County | at coral springs, fl | W | 47–37 | 6-2 | Kruel Classic | |
| Thu, Dec 21, 2000 | Ft. Lauderdale, FL | at coral springs, fl | L | 49–51 | 6-3 | Kruel Classic (championship) | |
| Wed, Dec 27, 2000 | Prestonsburg | at east carter | W | 78–42 | 7-3 | Queen of the Bluegrass | |
| Thu, Dec 28, 2000 | George Rogers Clark | at east carter | W | 70–39 | 8-3 | Queen of the Bluegrass | |
| Fri, Dec 29, 2000 | Russell | at east carter | W | 70–57 | 9-3 | Queen of the Bluegrass | |
| Sat, Dec 30, 2000 | Assumption | at east carter | L | 38–55 | 9-4 | Queen of the Bluegrass | |
| Tue, Jan 2, 2001 | Lafayette | away | W | 59–44 | 10-4 | ||
| Thu, Jan 4, 2001 | Lexington Christian | at paul dunbar | W | 62–28 | 11-4 | ||
| Thu, Jan 11, 2001 | Henry Clay | away | L | 77–79 | 11-5 | (overtime) | |
| Tue, Jan 16, 2001 | Franklin County | at paul dunbar | W | 84–34 | 12-5 | ||
| Thu, Jan 18, 2001 | Somerset | at paul dunbar | W | 62–51 | 13-5 | ||
| Mon, Jan 22, 2001 | Holmes | at paul dunbar | W | 78–53 | 14-5 | ||
| Sat, Jan 27, 2001 | Tates Creek | away | W | 75–36 | 15-5 | ||
| Mon, Jan 29, 2001 | Madison Central | at paul dunbar | W | 68–43 | 16-5 | ||
| Thu, Feb 1, 2001 | Scott County | away | W | 66–61 | 17-5 | ||
| Fri, Feb 2, 2001 | Bryan Station | away | L | 60–62 | 17-6 | ||
| Fri, Feb 9, 2001 | Lafayette | at paul dunbar | W | 67–36 | 18-6 | ||
| Mon, Feb 12, 2001 | Boyle County | away | W | 65–54 | 19-6 | ||
| Thu, Feb 15, 2001 | Henry Clay | at paul dunbar | L | 73–77 | 19-7 | (overtime) | |
| Mon, Feb 19, 2001 | Western Hills | at paul dunbar | W | 66–53 | 20-7 | ||
| Thu, Feb 22, 2001 | Harrison County | away | W | 48–35 | 21-7 | ||
| Wed, Feb 28, 2001 | Bryan Station | away | L | 65–70 | 21-8 | 2001 43rd District Girls Basketball Tournament |