Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 29, 2021 | Evansville Bosse (Evansville), IN | away | W | 50–31 | 1-0 | ||
| Tue, Nov 30, 2021 | Ohio County | home | W | 57–53 | 2-0 | ||
| Fri, Dec 3, 2021 | Evansville Christian School, IN | home | W | 59–28 | 3-0 | ||
| Sat, Dec 4, 2021 | Madisonville-North Hopkins | at owensboro catholic | L | 36–41 | 3-1 | Independence Bank Tip-Off Classic | |
| Tue, Dec 7, 2021 | Muhlenberg County | away | W | 45–44 | 4-1 | ||
| Fri, Dec 10, 2021 | Daviess County | away | L | 31–47 | 4-2 | ||
| Sat, Dec 11, 2021 | Meade County | home | L | 31–55 | 4-3 | ||
| Tue, Dec 14, 2021 | Hancock County | away | W | 60–55 | 5-3 | ||
| Fri, Dec 17, 2021 | Apollo | away | L | 53–66 | 5-4 | ||
| Mon, Dec 20, 2021 | Evansville Reitz (Evansville), IN | at owensboro sportscenter | L | 34–51 | 5-5 | ||
| Tue, Dec 21, 2021 | McLean County | at owensboro sportscenter | W | 42–22 | 6-5 | Independence Bank Kentucky-Indiana Classic | |
| Tue, Dec 28, 2021 | Rockcastle County | at south warren | L | 41–62 | 6-6 | ||
| Wed, Dec 29, 2021 | Marshall County | at south warren | L | 19–56 | 6-7 | ||
| Wed, Dec 29, 2021 | Oldham County | at south warren | W | 48–43 | 7-7 | ||
| Thu, Dec 30, 2021 | South Warren | away | L | 42–56 | 7-8 | FirstBank Holiday Bash | |
| Mon, Jan 3, 2022 | Grayson County | away | W | 28–23 | 8-8 | ||
| Sat, Jan 8, 2022 | Caldwell County | W | 67–54 | 9-8 | |||
| Mon, Jan 10, 2022 | Trinity (Whitesville) | home | W | 61–39 | 10-8 | ||
| Tue, Jan 11, 2022 | Union County | home | W | 54–38 | 11-8 | ||
| Sat, Jan 22, 2022 | Calloway County | away | W | 66–45 | 12-8 | ||
| Sat, Jan 29, 2022 | Henderson County | home | L | 31–74 | 12-9 | ||
| Wed, Feb 2, 2022 | Owensboro Catholic | home | L | 0–1 | 12-10 | (forfeit) | |
| Sat, Feb 5, 2022 | Apollo | home | W | 37–31 | 13-10 | ||
| Mon, Feb 7, 2022 | Breckinridge County | away | L | 36–59 | 13-11 | ||
| Wed, Feb 9, 2022 | Daviess County | home | L | 44–47 | 13-12 | ||
| Fri, Feb 11, 2022 | Owensboro Catholic | away | L | 41–59 | 13-13 | ||
| Sat, Feb 12, 2022 | Hopkinsville | home | L | 42–61 | 13-14 | ||
| Tue, Feb 15, 2022 | Butler County | away | L | 47–54 | 13-15 | ||
| Mon, Feb 21, 2022 | Owensboro Catholic | at daviess county | L | 31–58 | 13-16 | 2022 9th District Girls Basketball Tournament |