Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2021 | Bracken County | home | W | 21–13 | 1-0 | ||
| Fri, Aug 27, 2021 | Lockland, OH | away | L | 13–20 | 1-1 | ||
| Fri, Sep 3, 2021 | Open | 0–0 | |||||
| Fri, Sep 10, 2021 | Paris | home | L | 28–32 | 1-2 | ||
| Fri, Sep 17, 2021 | Carroll County | away | L | 20–61 | 1-3 | ||
| Fri, Sep 24, 2021 | Bishop Brossart | away | L | 7–41 | 1-4 | ||
| Fri, Oct 1, 2021 | Mason County | home | L | 9–32 | 1-5 | ||
| Thu, Oct 7, 2021 | Newport Central Catholic | away | L | 28–69 | 1-6 | ||
| Fri, Oct 15, 2021 | Bellevue | home | W | 40–0 | 2-6 | ||
| Fri, Oct 22, 2021 | Dayton | away | W | 49–6 | 3-6 | ||
| Fri, Oct 29, 2021 | Holy Cross (Covington) | home | L | 24–30 | 3-7 | ||
| Fri, Nov 5, 2021 | Dayton | home | L | 7–20 | 3-8 | 2021 Class 1A 2021 UK Orthopaedics State Football Finals |