Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Tue, Nov 30, 2021 | Henry Clay | home | W | 56–48 | 1-0 | ||
| Fri, Dec 3, 2021 | West Jessamine | home | L | 55–67 | 1-1 | ||
| Sat, Dec 4, 2021 | Fleming County | at harrison county | L | 46–51 | 1-2 | State Farm Tip-Off Classic | |
| Tue, Dec 7, 2021 | Montgomery County | home | W | 60–56 | 2-2 | ||
| Wed, Dec 15, 2021 | Bourbon County | home | 0–0 | COVID Cancelation - RPI per policy | |||
| Mon, Dec 20, 2021 | Whitley County | at bath county | L | 49–57 | 2-3 | Mike Bromagen Ladycats Legend Tournament | |
| Tue, Dec 21, 2021 | Powell County | at bath county | W | 56–45 | 3-3 | ||
| Wed, Dec 22, 2021 | Garrard County | at bath county | W | 55–50 | 4-3 | ||
| Wed, Dec 29, 2021 | Collins | at eminence | W | 54–40 | 5-3 | Eminence Holiday Tournament | |
| Wed, Dec 29, 2021 | Fern Creek | at eminence | W | 57–25 | 6-3 | ||
| Thu, Dec 30, 2021 | Marion County | at eminence | W | 44–38 | 7-3 | ||
| Tue, Jan 4, 2022 | George Rogers Clark | away | L | 31–50 | 7-4 | ||
| Sat, Jan 8, 2022 | St. Patrick | at bracken county | W | 58–39 | 8-4 | 10th Region All "A" Classic | |
| Mon, Jan 10, 2022 | Robertson County | at bracken county | W | 54–39 | 9-4 | ||
| Thu, Jan 13, 2022 | Bishop Brossart | at bracken county | W | 52–49 | 10-4 | 10th Region All "A" Classic | |
| Fri, Jan 14, 2022 | Scott | away | W | 64–57 | 11-4 | ||
| Fri, Jan 21, 2022 | George Rogers Clark | home | L | 24–51 | 11-5 | ||
| Sat, Jan 22, 2022 | Bourbon County | away | W | 43–40 | 12-5 | ||
| Wed, Jan 26, 2022 | Holy Cross (Covington) | at eku mcbrayer arena | L | 36–60 | 12-6 | All A State Tournament | |
| Fri, Jan 28, 2022 | Frederick Douglass | home | L | 48–60 | 12-7 | ||
| Tue, Feb 1, 2022 | Bath County | home | L | 45–48 | 12-8 | ||
| Wed, Feb 2, 2022 | Augusta | away | W | 52–47 | 13-8 | ||
| Sat, Feb 5, 2022 | Bourbon County | home | W | 52–35 | 14-8 | ||
| Mon, Feb 7, 2022 | Montgomery County | away | L | 49–58 | 14-9 | ||
| Tue, Feb 8, 2022 | Harrison County | away | W | 66–59 | 15-9 | (double overtime) | |
| Thu, Feb 10, 2022 | Mason County | home | W | 65–55 | 16-9 | ||
| Tue, Feb 15, 2022 | Tates Creek | away | L | 50–55 | 16-10 | ||
| Fri, Feb 18, 2022 | Robertson County | home | W | 73–15 | 17-10 | ||
| Mon, Feb 21, 2022 | Montgomery County | away | L | 30–54 | 17-11 | 2022 40th District Girls Basketball Tournament |