Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Mon, Nov 29, 2021 | Knox Central | home | L | 54–73 | 0-1 | ||
| Fri, Dec 3, 2021 | Mason County | away | L | 36–42 | 0-2 | ||
| Sat, Dec 4, 2021 | Bishop Brossart | at mason county | L | 29–60 | 0-3 | Lady Royals Showcase | |
| Sat, Dec 4, 2021 | Campbell County | at mason county | L | 57–60 | 0-4 | ||
| Mon, Dec 6, 2021 | Hazard | away | W | 1–0 | 1-4 | (forfeit) | |
| Tue, Dec 14, 2021 | Middlesboro | home | W | 57–42 | 2-4 | ||
| Thu, Dec 16, 2021 | Letcher County Central | away | L | 55–70 | 2-5 | ||
| Sat, Dec 18, 2021 | Lincoln County | at madison central | W | 64–58 | 3-5 | (overtime) | |
| Sun, Dec 19, 2021 | Henry Clay | at madison central | L | 61–72 | 3-6 | ||
| Mon, Dec 20, 2021 | Madison Central | away | L | 50–64 | 3-7 | ||
| Tue, Dec 21, 2021 | Pulaski County | at madison central | L | 53–83 | 3-8 | Jack Burford Chevy Christmas Classic | |
| Tue, Dec 28, 2021 | Lynn Camp | at williamsburg | W | 67–41 | 4-8 | Bill Perkins Holiday Classic | |
| Thu, Dec 30, 2021 | Williamsburg | away | W | 70–54 | 5-8 | ||
| Tue, Jan 4, 2022 | Oneida Baptist Institute | at williamsburg | W | 84–13 | 6-8 | 13th Region All "A" Classic | |
| Wed, Jan 12, 2022 | Barbourville | at williamsburg | W | 56–54 | 7-8 | ||
| Thu, Jan 13, 2022 | Jackson County | at williamsburg | L | 69–84 | 7-9 | 13th Region All "A" Classic | |
| Sat, Jan 15, 2022 | Harlan County | away | L | 62–73 | 7-10 | ||
| Mon, Jan 24, 2022 | Lynn Camp | home | W | 81–57 | 8-10 | ||
| Tue, Jan 25, 2022 | Bell County | away | L | 45–77 | 8-11 | ||
| Tue, Feb 1, 2022 | Bell County | home | L | 50–74 | 8-12 | ||
| Wed, Feb 2, 2022 | Leslie County | away | L | 73–84 | 8-13 | ||
| Sat, Feb 5, 2022 | Middlesboro | away | L | 52–55 | 8-14 | ||
| Tue, Feb 8, 2022 | Harlan County | home | L | 53–65 | 8-15 | ||
| Fri, Feb 11, 2022 | Corbin | home | L | 58–79 | 8-16 | ||
| Sat, Feb 12, 2022 | Betsy Layne | away | L | 33–51 | 8-17 | ||
| Mon, Feb 14, 2022 | Red Bird | home | W | 74–63 | 9-17 | ||
| Mon, Feb 21, 2022 | Bell County | away | L | 46–81 | 9-18 | 2022 52nd District Girls Basketball Tournament |