Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Tue, Nov 30, 2021 | Western | away | W | 43–18 | 1-0 | ||
| Fri, Dec 3, 2021 | Brown | away | W | 25–15 | 2-0 | ||
| Tue, Dec 7, 2021 | Shawnee | away | L | 27–43 | 2-1 | ||
| Fri, Dec 10, 2021 | Moore | away | L | 26–47 | 2-2 | ||
| Tue, Dec 14, 2021 | North Bullitt | home | L | 18–52 | 2-3 | ||
| Fri, Dec 17, 2021 | Doss | at western | W | 49–33 | 3-3 | Louisville Western Holiday Classic | |
| Sat, Dec 18, 2021 | Waggener | at western | W | 27–26 | 4-3 | ||
| Sat, Dec 18, 2021 | Iroquois | at western | W | 37–27 | 5-3 | Western Girls Holiday Hoops Classic | |
| Sun, Dec 19, 2021 | Jeffersontown | at western | L | 33–44 | 5-4 | Louisville Western Holiday Classic | |
| Tue, Jan 4, 2022 | Waggener | away | L | 0–1 | 5-5 | COVID Cancelation - RPI per Policy | |
| Thu, Jan 6, 2022 | Seneca | away | L | 0–1 | 5-6 | COVID Cancelation - RPI per Policy | |
| Mon, Jan 10, 2022 | Highlands Latin | away | L | 41–42 | 5-7 | ||
| Tue, Jan 18, 2022 | Central | home | L | 17–81 | 5-8 | ||
| Tue, Jan 25, 2022 | Beth Haven | away | W | 48–34 | 6-8 | ||
| Sat, Jan 29, 2022 | Newport | home | L | 22–57 | 6-9 | ||
| Tue, Feb 1, 2022 | Ballard | away | L | 16–56 | 6-10 | ||
| Tue, Feb 8, 2022 | DuPont Manual | away | L | 10–87 | 6-11 | ||
| Wed, Feb 9, 2022 | Sacred Heart | away | L | 13–82 | 6-12 | ||
| Mon, Feb 14, 2022 | Southern | away | W | 58–12 | 7-12 | ||
| Tue, Feb 15, 2022 | Holy Cross (Louisville) | home | L | 29–55 | 7-13 | ||
| Thu, Feb 17, 2022 | Seneca | home | W | 52–15 | 8-13 | ||
| Mon, Feb 21, 2022 | Waggener | away | W | 52–14 | 9-13 | 2022 27th District Girls Basketball Tournament | |
| Tue, Feb 22, 2022 | Sacred Heart | at waggener | L | 18–63 | 9-14 | 2022 27th District Girls Basketball Tournament |