Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2021 | Mason County | home | L | 7–16 | 0-1 | ||
| Fri, Aug 27, 2021 | Bishop Brossart | home | L | 7–21 | 0-2 | ||
| Fri, Sep 3, 2021 | Pendleton County | away | W | 1–0 | 1-2 | COVID Cancelation - RPI per policy | |
| Fri, Sep 10, 2021 | Holmes | away | L | 8–38 | 1-3 | ||
| Thu, Sep 16, 2021 | Cincinnati College Prep Academy (Cincinnati), OH | home | L | 6–34 | 1-4 | ||
| Sat, Sep 25, 2021 | Newport Central Catholic | home | L | 14–43 | 1-5 | ||
| Fri, Oct 1, 2021 | Bellevue | home | W | 48–0 | 2-5 | ||
| Fri, Oct 8, 2021 | Lloyd Memorial | home | W | 21–14 | 3-5 | (overtime) | |
| Fri, Oct 15, 2021 | Holy Cross (Covington) | away | L | 14–47 | 3-6 | ||
| Fri, Oct 22, 2021 | Beechwood | away | L | 0–54 | 3-7 | ||
| Fri, Oct 29, 2021 | Pendleton County | away | W | 3–0 | 4-7 | (overtime) | |
| Fri, Nov 5, 2021 | Beechwood | away | L | 8–58 | 4-8 | 2021 Class 2A 2021 UK Orthopaedics State Football Finals |