Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Hancock County | home | W | 34–0 | 1-0 | ||
| Fri, Aug 27, 2010 | Muhlenberg County | away | W | 48–0 | 2-0 | ||
| Fri, Sep 3, 2010 | Breckinridge County | home | W | 47–0 | 3-0 | ||
| Fri, Sep 10, 2010 | Todd County Central | away | W | 49–2 | 4-0 | ||
| Fri, Sep 17, 2010 | Barren County | away | W | 40–0 | 5-0 | ||
| Fri, Sep 24, 2010 | Clinton County | home | W | 55–0 | 6-0 | ||
| Fri, Oct 1, 2010 | Bowling Green | home | L | 27–41 | 6-1 | ||
| Fri, Oct 8, 2010 | Butler County | home | W | 48–3 | 7-1 | ||
| Fri, Oct 15, 2010 | Warren Central | away | L | 6–24 | 7-2 | ||
| Fri, Oct 22, 2010 | Edmonson County | home | W | 23–0 | 8-2 | ||
| Fri, Nov 5, 2010 | Owensboro | away | W | 28–22 | 9-2 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Warren Central | away | L | 8–10 | 9-3 | 2010 Class 5A KHSAA Commonwealth Gridiron Bowl |