Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Prestonsburg | home | L | 6–21 | 0-1 | ||
| Fri, Aug 27, 2010 | Holy Cross (Covington) | at pikeville/shelby valley | W | 20–14 | 1-1 | ||
| Fri, Sep 3, 2010 | Ashland Blazer | away | L | 22–36 | 1-2 | ||
| Fri, Sep 10, 2010 | Letcher County Central | home | W | 42–20 | 2-2 | ||
| Fri, Sep 17, 2010 | Whitley County | home | W | 27–21 | 3-2 | ||
| Fri, Oct 1, 2010 | Pikeville | away | W | 55–24 | 4-2 | ||
| Fri, Oct 8, 2010 | Pike County Central | home | W | 34–18 | 5-2 | ||
| Fri, Oct 15, 2010 | Sheldon Clark | away | L | 6–22 | 5-3 | ||
| Fri, Oct 22, 2010 | East Ridge | home | W | 52–0 | 6-3 | ||
| Fri, Oct 29, 2010 | Johnson Central | away | L | 7–42 | 6-4 | ||
| Fri, Nov 5, 2010 | West Carter | home | W | 42–7 | 7-4 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Mason County | away | W | 27–14 | 8-4 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Russell | home | W | 42–14 | 9-4 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Somerset | home | W | 28–23 | 10-4 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Sat, Dec 4, 2010 | Central | at houchens-l.t. smith stadium, wku | L | 7–46 | 10-5 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl |