Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2021 | Lexington Christian | home | L | 12–21 | 0-1 | ||
| Fri, Aug 27, 2021 | Paul Laurence Dunbar | away | W | 34–24 | 1-1 | ||
| Fri, Sep 3, 2021 | Madison Southern | home | W | 1–0 | 2-1 | COVID Cancelation - RPI per policy | |
| Fri, Sep 10, 2021 | South Laurel | home | W | 69–6 | 3-1 | ||
| Fri, Sep 17, 2021 | Lafayette | away | W | 49–0 | 4-1 | ||
| Fri, Sep 24, 2021 | Open | 0–0 | |||||
| Fri, Oct 1, 2021 | Pikeville | home | W | 21–19 | 5-1 | ||
| Fri, Oct 8, 2021 | Oldham County | away | W | 31–15 | 6-1 | ||
| Fri, Oct 15, 2021 | George Rogers Clark | away | W | 43–7 | 7-1 | ||
| Fri, Oct 22, 2021 | Bryan Station | home | L | 13–21 | 7-2 | ||
| Fri, Oct 29, 2021 | Southwestern | L | 0–26 | 7-3 | |||
| Fri, Nov 5, 2021 | Oldham County | home | W | 42–9 | 8-3 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals | |
| Fri, Nov 12, 2021 | Bryan Station | away | W | 41–18 | 9-3 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals | |
| Fri, Nov 19, 2021 | Paul Laurence Dunbar | home | W | 43–7 | 10-3 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals | |
| Fri, Nov 26, 2021 | St. Xavier | away | L | 21–31 | 10-4 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals |