Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2021 | Meade County | away | W | 30–0 | 1-0 | ||
| Fri, Aug 27, 2021 | Owensboro Catholic | home | W | 56–19 | 2-0 | ||
| Fri, Sep 3, 2021 | Owensboro | home | L | 42–49 | 2-1 | ||
| Fri, Sep 10, 2021 | Floyd Central (Floyds Knobs), IN | away | W | 21–14 | 3-1 | OT | |
| Fri, Sep 17, 2021 | Madisonville-North Hopkins | away | W | 49–22 | 4-1 | ||
| Fri, Sep 24, 2021 | Marshall County | home | W | 71–7 | 5-1 | ||
| Fri, Oct 1, 2021 | McCracken County | away | W | 51–20 | 6-1 | ||
| Fri, Oct 8, 2021 | Open | 0–0 | |||||
| Fri, Oct 15, 2021 | Henderson County | home | W | 38–17 | 7-1 | ||
| Fri, Oct 22, 2021 | Apollo | away | W | 43–21 | 8-1 | ||
| Fri, Oct 29, 2021 | Warren East | home | W | 58–14 | 9-1 | ||
| Fri, Nov 5, 2021 | McCracken County | home | W | 55–31 | 10-1 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals | |
| Fri, Nov 12, 2021 | Henderson County | home | W | 51–28 | 11-1 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals | |
| Fri, Nov 19, 2021 | St. Xavier | away | L | 6–42 | 11-2 | 2021 Class 6A 2021 UK Orthopaedics State Football Finals |