Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 26, 2016 | Lexington Catholic | away | W | 42–28 | 1-0 | ||
| Fri, Sep 2, 2016 | Bowling Green | away | L | 10–31 | 1-1 | ||
| Fri, Sep 9, 2016 | Central | home | W | 51–7 | 2-1 | ||
| Fri, Sep 16, 2016 | Highlands | home | W | 45–18 | 3-1 | ||
| Fri, Sep 23, 2016 | Pleasure Ridge Park | home | W | 27–17 | 4-1 | ||
| Fri, Sep 30, 2016 | Trinity (Louisville) | L | 13–35 | 4-2 | |||
| Fri, Oct 7, 2016 | DuPont Manual | home | W | 28–12 | 5-2 | ||
| Fri, Oct 14, 2016 | Male | away | W | 31–21 | 6-2 | ||
| Fri, Oct 21, 2016 | Butler | away | W | 35–6 | 7-2 | ||
| Fri, Oct 28, 2016 | Cincinnati St. Xavier, OH | away | L | 3–28 | 7-3 | ||
| Fri, Nov 4, 2016 | Muhlenberg County | home | W | 63–14 | 8-3 | 2016 Class 6A Russell Athletic/KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 11, 2016 | DuPont Manual | home | W | 42–26 | 9-3 | 2016 Class 6A Russell Athletic/KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 18, 2016 | Male | home | W | 31–21 | 10-3 | 2016 Class 6A Russell Athletic/KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 25, 2016 | Trinity (Louisville) | away | L | 14–24 | 10-4 | 2016 Class 6A Russell Athletic/KHSAA Commonwealth Gridiron Bowl |