Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 20, 2010 | Hopkinsville | away | L | 20–31 | 0-1 | ||
| Fri, Aug 27, 2010 | Gateway, MO | home | W | 20–16 | 1-1 | ||
| Fri, Sep 3, 2010 | Mayfield | away | L | 20–23 | 1-2 | overtime | |
| Fri, Sep 10, 2010 | Graves County | home | W | 42–6 | 2-2 | ||
| Fri, Sep 17, 2010 | Fort Campbell | home | W | 41–10 | 3-2 | ||
| Fri, Sep 24, 2010 | Calloway County | away | W | 65–29 | 4-2 | ||
| Fri, Oct 1, 2010 | Webster County | away | W | 41–21 | 5-2 | ||
| Fri, Oct 8, 2010 | Union County | home | W | 21–18 | 6-2 | ||
| Fri, Oct 15, 2010 | McLean County | home | W | 66–7 | 7-2 | ||
| Sat, Oct 23, 2010 | Holy Cross (Louisville) | away | W | 31–7 | 8-2 | ||
| Fri, Nov 5, 2010 | Butler County | home | W | 45–9 | 9-2 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 12, 2010 | Edmonson County | home | W | 42–14 | 10-2 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 19, 2010 | Russellville | away | W | 17–14 | 11-2 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl | |
| Fri, Nov 26, 2010 | Central | away | L | 18–35 | 11-3 | 2010 Class 3A KHSAA Commonwealth Gridiron Bowl |