Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 17, 2001 | Hopkinsville | at trigg county | W | 41–35 | 1-0 | Integra Bank Bowl | |
| Sat, Aug 25, 2001 | Highlands | away | W | 30–0 | 2-0 | (suspended at half time) St. Luke Hospitals… | |
| Fri, Aug 31, 2001 | Seneca | home | W | 50–19 | 3-0 | ||
| Fri, Sep 7, 2001 | Lexington Catholic | home | W | 1–0 | 4-0 | (forfeit) | |
| Fri, Sep 14, 2001 | Atherton | away | W | 63–14 | 5-0 | ||
| Fri, Sep 21, 2001 | Owensboro | home | W | 55–21 | 6-0 | ||
| Fri, Sep 28, 2001 | Southern | home | W | 72–7 | 7-0 | ||
| Thu, Oct 4, 2001 | Central | home | W | 42–16 | 8-0 | ||
| Fri, Oct 19, 2001 | St. Xavier | at manual stadium | W | 28–20 | 9-0 | ||
| Fri, Oct 26, 2001 | DuPont Manual | away | L | 13–20 | 9-1 | ||
| Fri, Nov 2, 2001 | Butler | at male (g1 of doubleheader) | W | 44–0 | 10-1 | 2001 Class AAAA Football State Tournament | |
| Fri, Nov 9, 2001 | Pleasure Ridge Park | home | W | 25–22 | 11-1 | 2001 Class AAAA Football State Tournament | |
| Fri, Nov 16, 2001 | Meade County | home | W | 33–14 | 12-1 | 2001 Class AAAA Football State Tournament | |
| Fri, Nov 23, 2001 | Owensboro | away | W | 23–6 | 13-1 | 2001 Class AAAA Football State Tournament | |
| Sat, Dec 1, 2001 | Trinity (Louisville) | at ky. fair & expo center cardinal stadium | L | 19–45 | 13-2 | 2001 Class AAAA Football State Tournament |