Schedule & results
| Date | Opponent | Site | Score | Record | Event | ||
|---|---|---|---|---|---|---|---|
| Fri, Aug 18, 2000 | Pike County Central | home | W | 60–0 | 1-0 | Pike County Bowl | |
| Fri, Aug 25, 2000 | Dayton | away | W | 48–0 | 2-0 | ||
| Fri, Sep 1, 2000 | Dayton Jefferson, OH | away | W | 33–0 | 3-0 | ||
| Fri, Sep 8, 2000 | Mason County | home | W | 49–7 | 4-0 | ||
| Fri, Sep 15, 2000 | Rowan County | away | W | 33–9 | 5-0 | ||
| Fri, Sep 22, 2000 | Open | ||||||
| Fri, Sep 29, 2000 | Holy Cross (Covington) | home | W | 53–3 | 6-0 | (District Game) | |
| Fri, Oct 6, 2000 | Beechwood | away | L | 0–10 | 6-1 | (District Game) | |
| Fri, Oct 13, 2000 | Ludlow | away | W | 49–6 | 7-1 | (District Game) | |
| Fri, Oct 20, 2000 | Newport Central Catholic | home | W | 22–20 | 8-1 | (District Game) | |
| Fri, Oct 27, 2000 | Dayton | home | W | 47–7 | 9-1 | (District Game) | |
| Fri, Nov 3, 2000 | Paris | home | W | 33–13 | 10-1 | 2000 Class A Tournament | |
| Fri, Nov 10, 2000 | Nicholas County | away | W | 36–9 | 11-1 | 2000 Class A Tournament | |
| Fri, Nov 17, 2000 | Newport Central Catholic | home | L | 20–38 | 11-2 | 2000 Class A Tournament |